Clinical Practice Guidelines: Methodological Considerations

Clinical Practice Guidelines EASL Clinical Practice Guidelines: Wilson’s disease

This Clinical Practice Guideline (CPG) has been developed to assist physicians and other healthcare providers in the diagnosis and management of patients with Wilson’s disease. The goal is to describe a number of generally accepted approaches for diagnosis, prevention, and treatment of Wilson’s disease. Recommendations are based on a systematic literature review in the Medline (PubMed version),...

NHG Clinical Practice Guidelines NHG Clinical Practice Guidelines

Testing bias in clinical databases: methodological considerations

BACKGROUND Laboratory testing in clinical practice is never a random process. In this study we evaluated testing bias for neutrophil counts in clinical practice by using results from requested and non-requested hematological blood tests. METHODS This study was conducted using data from the Utrecht Patient Oriented Database. This clinical database is unique, as it contains physician requested ...

Clinical Practice Guidelines: Principles for Clinical Practice

S5 print and electronic media where they come across lay guidelines; doctors need to inform the patients regarding available treatment alternatives, their potential harms and benefits, where clinical guidelines work as the best available educative tool. CPGs highlight gaps in known literature where treatment recommendations are not clear cut; hence it helps in identifying areas where future res...

Computer-interpretable clinical guidelines: A methodological review

Clinical practice guidelines (CPGs) aim to improve the quality of care, reduce unjustified practice variations and reduce healthcare costs. In order for them to be effective, clinical guidelines need to be integrated with the care flow and provide patient-specific advice when and where needed. Hence, their formalization as computer-interpretable guidelines (CIGs) makes it possible to develop CI...